Omez

 

Indication & Usage

Initial treatment for gastroesophageal reflux disease: No signs of erosive esophagitis and mild/intermittent illness (2 episodes/week) Oral: 10 mg once daily; if necessary, after 4 to 8 weeks, increase to 20 mg once daily. Once asymptomatic for eight weeks, stop taking it. Severe symptoms (more than two occurrences per week) and/or erosive esophagitis: Oral: 20 to 40 mg once day; continue for at least 8 weeks once symptoms are under control. -Oral: 20 mg or 40 mg twice day as part of a suitable combination regimen with antibiotics for the eradication of Helicobacter pylori.

Primary prevention of ulcers brought on by nonsteroidal anti-inflammatory drugs (including aspirin): For the duration of high-risk NSAID usage, oral: 20 mg once day. Treatment of peptic ulcer disease and secondary prevention: straightforward ulcer 20 to 40 mg orally, once day. The time frame might last anywhere between 4 and 8 weeks, depending on the size, location, and origin of the ulcer. It's possible to raise the dosage to 20 to 40 mg twice daily in people with resistant or recurrent illness.

For a complicated ulcer (one with a perforation, penetration, or blockage of the stomach outlet), the oral dosage is 40 mg twice day for four weeks, then 40 mg once daily. The length of time varies on the ulcer's location and cause. -Prophylaxis for stress ulcers in some critically sick patients: Orally or through an NG tube: 40 mg once daily or 40 mg initially, followed by another 40 mg dosage given 6 to 8 hours later. Once a serious condition has passed and modifiable risk factors have disappeared, prophylaxis should be stopped. -Erosive esophagitis: Infants, children, and adolescents: Oral 2.5 mg once daily for 3 to 5 kg. 5 mg once a day for 5 to 10 kg. 10 mg once a day for 10 kg to 20 kg. 20 kg: once daily 20 mg. Continuation dose: Oral: Children and adolescents

2.5 mg once daily for 3 to 5 kg. 5 mg once a day for 5 to 10 kg. 10 mg once a day for 10 kg to 20 kg. 20 kg: once daily 20 mg. Continuation dose: Children and teenagers: 5 to 10 kg: 5 mg once daily when taken orally. 10 mg once a day for 10 kg to 20 kg. 20 kg: once daily 20 mg. The length of therapy depends on age: Infants can last up to 6 weeks, while kids and teenagers can last 4 to 8 weeks.

Dosage & Administration

-Take before breakfast; provide 30 to 60 minutes before a meal. If taking two doses a day, the first one should be taken before breakfast and the second before supper. It is unclear what preendoscopic PPI treatment is ideal. In patients with suspected active upper GI bleeding, some experts advise starting high-dose IV PPI with continuous or intermittent dosage prior to endoscopy. Following endoscopy, it is advised to provide an IV PPI continuously for at least 72 hours before switching to an oral PPI for patients who have high-risk signs of recent bleeding (such as a current bleed, a visible vessel, or an adhering clot).

Side Effects

-omeprazole, including gastroenteritis and diarrhoea caused by Clostridioides difficile, may increase the risk of enteric infections in both adult and paediatric patients (CDAD). Including omeprazole, long-term usage of acid-suppressing medications might cause reversible vitamin B12 deficiency. Skin rash, upper respiratory infection, asthenia, stomach discomfort, constipation, diarrhoea, flatulence, nausea, and vomiting are all symptoms of respiratory disorders.

Safety Advice

-In order to prevent worsening or rebound symptoms in patients who have undergone continuous therapy for more than six months, reduce therapy gradually until cessation. Reduce the dosage given to the patient, who is now taking 40 mg once or twice per day, by 50% each week. The initial dosage decrease for individuals receiving twice-daily treatment can be accomplished by switching to once-daily dosing. -Hepatic Disorder: Adult: 10 mg once daily when used to maintain erosive esophagitis healing in patients with mild to severe impairment. - Use should be avoided if you have a history of omeprazole hypersensitivity, including anaphylaxis, anaphylactic shock, angioedema, bronchospasm, acute tubulointerstitial nephritis, and urticaria. - Long-term therapy (more than two years) increases the risk of vitamin B12 malabsorption and eventual deficiency. -If you take more than you should, be prepared to explain or prove it.

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Drug Interactions

-Bisphosphonate Derivatives: PPIs and PCABs, which inhibit the proton pump, may reduce the therapeutic impact of bisphosphonate derivatives. -Cefpodoxime: Proton Pump Inhibitors (PPIs and PCABs) may lower Cefpodoxime serum levels. Cefuroxime: Proton Pump Inhibitors (PPIs and PCABs) may reduce Cefuroxime absorption. -Cilostazol: Omeprazole may raise blood levels of Cilostazol's active metabolite(s). -Citalopram: Omeprazole may raise Citalopram's serum levels. Clopidogrel: Omeprazole may lessen Clopidogrel's antiplatelet action. -Doxycycline: Proton Pump Inhibitors (PPIs and PCABs) may reduce Doxycycline's bioavailability. -Escitalopram: Omeprazole may raise Escitalopram's serum levels. -Gliclazide: Omeprazole may raise Gliclazide's serum levels.

-Itraconazole: Proton Pump Inhibitors (PPIs and PCABs) may raise Itraconazole's serum levels. -Methotrexate: Proton Pump Inhibitors (PPIs and PCABs) may raise Methotrexate's serum levels. Inhibitors of the proton pump (PPIs and PCABs) may lower the serum concentration of multivitamins and minerals (with vitamins ADEK, Folate, and Iron) (with vitamins ADEK, Folate, Iron). -Vitamin K Antagonists (such as warfarin): Omeprazole may raise the level of Vitamin K Antagonists in the blood.

Pregnancy & Lactation

-Data currently available do not indicate a higher risk of serious birth abnormalities following omeprazole usage by the pregnant mother. PPIs may be utilised when clinically necessary based on the evidence currently available. - Breast milk contains omeprazole. Omeprazole's relative infant dose (RID) ranges from 0.2% to 0.43%. When the RID is less than 10%, breastfeeding is generally regarded as appropriate.